Limonard C B
Clin Chim Acta. 1979 Jun 1;94(2):137-54. doi: 10.1016/0009-8981(79)90007-x.
Based on the time variant behaviour of analytical processes, a dynamic system of deviation control is discussed. Originating from industrial process control, measurability and controllability rules as measures of the optimum reconstructing and controlling efficiency of quality control systems are introduced. It is seen that when trying to reconstruct and control and analytical process, properties of the process and characteristics of the control system need to be taken into consideration. Application of these rules offers the possibility of investigating the effect of actions aimed at improving the performance of a controlling system, but also indicates if a certain precision requirement can be achieved with less effort and expense. An example illustrates the time variant behaviour of an analytical process used for urea determination in a clinical chemistry laboratory. It shows the applicability of measurability and controllability rules, with the emphasis on the measuring or reconstructing efficiency of the controlling system used in that laboratory for the surveillance of the urea determination.
基于分析过程的时变行为，讨论了偏差控制的动态系统。源于工业过程控制，引入了可测量性和可控性规则，作为质量控制系统最佳重构和控制效率的度量。可以看出，在尝试重构和控制分析过程时，需要考虑过程的特性和控制系统的特征。应用这些规则不仅提供了研究旨在提高控制系统性能的行动效果的可能性，还表明是否可以用更少的努力和费用实现特定的精度要求。一个例子说明了临床化学实验室中用于尿素测定的分析过程的时变行为。它展示了可测量性和可控性规则的适用性，重点是该实验室用于监测尿素测定的控制系统的测量或重构效率。
