血管紧张素II拮抗剂沙拉新对正常受试者钠耗竭前及钠耗竭期间血浆醛固酮浓度和血压的影响。

Effect of the angiotensin II antagonist saralasin on plasma aldosterone concentration and on blood pressure before and during sodium depletion in normal subjects.

作者信息

Agabiti-Rosei E, Brown J J, Brown W C, Fraser R, Trust P M, Lever A F, Morton J J, Robertson J I

出版信息

Clin Endocrinol (Oxf). 1979 Mar;10(3):227-34. doi: 10.1111/j.1365-2265.1979.tb02076.x.

DOI:10.1111/j.1365-2265.1979.tb02076.x

Abstract

The effect of the angiotensin II antagonist saralasin on plasma aldosterone, plasma angiotensin II and blood pressure was studied in six normal supine subjects both before and during sodium depletion. Before sodium depletion, infusion of saralasin produced no consistent changes; during sodium depletion, infusion of the angiotensin antagonist caused a fall in plasma aldosterone and an increase in plasma angiotensin II in each subject. It is concluded that angiotensin II plays a major part in stimulating aldosterone secretion during sodium depletion in man.

摘要

在六名正常仰卧受试者中，研究了血管紧张素II拮抗剂沙拉新在钠耗竭前后对血浆醛固酮、血浆血管紧张素II和血压的影响。在钠耗竭前，输注沙拉新未产生一致的变化；在钠耗竭期间，输注血管紧张素拮抗剂导致每位受试者的血浆醛固酮下降，血浆血管紧张素II升高。得出的结论是，在人体钠耗竭期间，血管紧张素II在刺激醛固酮分泌中起主要作用。