Fagard R, Lijnen P, Amery A, Reybrouck T
Contrib Nephrol. 1978;11:175-8. doi: 10.1159/000401800.
1-Sar-8-ala-angiotensin II did not change intra-arterial pressure in 25 sodium replete hypertensive patients, whilst the pressure changes were closely related to the plasma renin level during sodium depletion (r = -0.87; n = 32). The study indicates that arterial pressure is not dependent on angiotensin II in sodium replete patients and in sodium deplete subjects with low PRC, while it is angiotensin dependent during sodium depletion in the others. Plasma renin is unaffected in sodium replete subjects, but increases during saralasin in sodium deplete conditions. Saralasin stimulates aldosterone secretion only in sodium replete patients.
在25例钠储备充足的高血压患者中，1-肌氨酸-8-丙氨酸血管紧张素II未改变动脉内压力，而在钠缺乏时压力变化与血浆肾素水平密切相关（r = -0.87；n = 32）。该研究表明，在钠储备充足的患者以及血浆肾素浓度（PRC）较低的钠缺乏受试者中，动脉压力不依赖于血管紧张素II，而在其他受试者钠缺乏期间，动脉压力则依赖于血管紧张素。钠储备充足的受试者血浆肾素不受影响，但在钠缺乏情况下使用沙拉新时会升高。沙拉新仅在钠储备充足的患者中刺激醛固酮分泌。
