Murthy S N, Dinoso V P, Clearfield H R, Chey W Y
Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania 19102.
Gastroenterology. 1978 Jul;75(1):1-4.
The effect of smoking on the pH of the duodenal bulb was studied in 10 normosecretors and 10 hypersecretors using a Beckman pH electrode. The pH was monitored during three study periods, basal, smoking, and postsmoking, of 1 hr each. The pH remained below 3.5 significantly longer during the smoking period compared to the basal period for both groups. The bulbar pH remained under 3.5 during the smoking period longer in the hypersecretor group compared to the normosecretor group (60 versus 20%). Hypersecretors who were smokers exhibited acidic bulbar pH values longer and more consistently than hypersecretor-nonsmokers during smoking. In 5 hypersecretors with data for both bulbar pH and bicarbonate output, inhibition of bicarbonate output during smoking was generally associated with acidic pH values in the bulb. These observations suggest that the association between cigarette smoking and peptic ulcer disease may be attributable to, in part, the persistently acidic pH values in the duodenal bulb during smoking. This study further suggests that the degree and the duration of acidification of the duodenal bulb during smoking are influenced by the secretory and the smoking status of the subject.
使用贝克曼pH电极，对10名正常分泌者和10名高分泌者研究了吸烟对十二指肠球部pH值的影响。在三个研究阶段监测pH值，每个阶段1小时，分别为基础期、吸烟期和吸烟后期。与基础期相比，两组在吸烟期pH值显著低于3.5的时间更长。与正常分泌者组相比，高分泌者组在吸烟期十二指肠球部pH值低于3.5的时间更长（60%对20%）。在吸烟过程中，吸烟的高分泌者比不吸烟的高分泌者十二指肠球部pH值呈酸性的时间更长且更持续。在5名同时有十二指肠球部pH值和碳酸氢盐分泌量数据的高分泌者中，吸烟期间碳酸氢盐分泌量的抑制通常与十二指肠球部的酸性pH值相关。这些观察结果表明，吸烟与消化性溃疡疾病之间的关联可能部分归因于吸烟期间十二指肠球部持续的酸性pH值。这项研究进一步表明，吸烟期间十二指肠球部酸化的程度和持续时间受受试者的分泌状态和吸烟状态影响。
