Ramesh G N, Kochhar R, Broor S L, Ghosh P, Sharma B K, Mehta S K
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Gastroenterol Hepatol. 1989 May-Jun;4(3):259-63. doi: 10.1111/j.1440-1746.1989.tb00833.x.
The effect of smoking on gastric secretion was studied in 15 consecutive patients with duodenal ulcer--six normosecretors (basal acid output less than or equal to 3 mEq/h), and nine hypersecretors (basal acid output greater than 3 mEq/h). The volume, acid output, acid concentration, and pH of the gastric juice measured before, during and after 1 h of smoking did not show any significant difference in these patients taken as a single group, or when the normosecretors and hypersecretors were analysed as separate groups (P greater than 0.05 for each parameter in each group). The higher acid output before and during smoking in hypersecretors than in normosecretors was due to the higher acid concentration in the gastric juice (P less than 0.01). Study of the pH curves of the gastric juice after acute smoking showed that hypersecretors had a lower pH for a longer duration compared with normosecretors. This could make the hypersecretors with a history of chronic smoking more prone to developing duodenal ulcer.
对15例十二指肠溃疡患者的吸烟对胃分泌的影响进行了研究，其中6例为正常分泌者（基础酸排出量≤3 mEq/h），9例为高分泌者（基础酸排出量＞3 mEq/h）。在吸烟前、吸烟期间及吸烟后1小时测量的胃液量、酸排出量、酸浓度及pH值，在将这些患者作为一个整体研究时，或在将正常分泌者和高分泌者作为单独的组进行分析时，均未显示出任何显著差异（每组各参数的P均＞0.05）。高分泌者吸烟前及吸烟期间的酸排出量高于正常分泌者，这是由于胃液中酸浓度较高所致（P＜0.01）。对急性吸烟后胃液pH曲线的研究表明，与正常分泌者相比，高分泌者的pH值在更长时间内较低。这可能使有长期吸烟史的高分泌者更易发生十二指肠溃疡。
