Penn I, Durst A L, Machado M, Halgrimson C G, Booth A S, Putman C W, Groth C G, Starzl T E
Arch Surg. 1972 Aug;105(2):167-72. doi: 10.1001/archsurg.1972.04180080021004.
In a series of 301 renal homograft recipients, 17 (5.6%) had acute pancreatitis at some time after transplantation. Eleven of these patients died, for a mortality of 64.7%. In each instance, pancreatitis was a major factor in a complex chain of lethal events to which immunosuppression invariably contributed. An additional 43 patients (14.3%) developed asymptomatic hyperamylasemia after transplantation and, undoubtedly, some of these recipients also had pancreatitis. The factors causing pancreatitis in the renal transplantation patient include uremia, hyperparathyroidism, pancreatic injury by drugs, infections resulting from chronic immunosuppression, gallstones, and operative trauma to the pancreas. In cases of preexisting pancreatitis, transplantation is not necessarily precluded, but efforts should be made to find a specific cause of the pancreatitis and take corrective measures, such as biliary tract surgery or parathyroidectomy if indicated, in advance of transplantation.
在一组301例同种异体肾移植受者中，17例（5.6%）在移植后的某个时间发生了急性胰腺炎。其中11例患者死亡，死亡率为64.7%。在每一个病例中，胰腺炎都是一系列致命事件复杂链条中的一个主要因素，免疫抑制在其中总是起到了促成作用。另外43例患者（14.3%）在移植后出现了无症状性高淀粉酶血症，毫无疑问，这些受者中的一些也患有胰腺炎。导致肾移植患者发生胰腺炎的因素包括尿毒症、甲状旁腺功能亢进、药物对胰腺的损伤、慢性免疫抑制导致的感染、胆结石以及胰腺的手术创伤。对于既往存在胰腺炎的病例，不一定必须排除移植，但应努力寻找胰腺炎的具体病因，并在移植前采取纠正措施，如在有指征时进行胆道手术或甲状旁腺切除术。
