Imokawa G, Mishima Y
Contact Dermatitis. 1979 May;5(3):151-62. doi: 10.1111/j.1600-0536.1979.tb04828.x.
In order to analyze the role of various surfactants in the abnormal desquamation process of the epidermis in keratodermia type hand dermatitis, the lysosome labilizing effect of surfactants has been investigated by measuring the release of enzymes from lysosomes in vitro using spectrophotometric and gel chromatographic techniques. It has been found that the labilizing effect of surfactants decreases in the order of cationic, anionic, and nonionic surfactants and varies with its alkyl chain length. The relationship of the labilization and skin roughness inducing effect is also discussed.
为了分析各种表面活性剂在角化型手部皮炎表皮异常脱屑过程中的作用，采用分光光度法和凝胶色谱技术，通过测量体外溶酶体中酶的释放，研究了表面活性剂对溶酶体的不稳定作用。结果发现，表面活性剂的不稳定作用按阳离子、阴离子和非离子表面活性剂的顺序递减，并随其烷基链长度而变化。还讨论了不稳定作用与皮肤粗糙度诱导作用之间的关系。
