Bastert G, Steinau U, Fortmeyer H P, Eichholz H, Schmidt-Matthiesen H
Chir Forum Exp Klin Forsch. 1979:175-8.
Of 150 human breast cancers, 90 (60%) were successfully transplanted onto thymusaplastic nude mice without the use of adjunctive immunosuppressive therapy. Four months after transplantation, 12 rapidly growing tumors had diameters of 2.5-3.5 cm. Investigations revealed a high correlation between the histology of original tumors and xenografts. We conclude that the nude mouse may be used as an animal model for studies such as this, or in determining the sensitivity of transplanted tumors to cytostatic drugs, steroid hormones, and radiation.
在150例人类乳腺癌中，90例（60%）在未使用辅助免疫抑制治疗的情况下成功移植到无胸腺裸鼠体内。移植四个月后，12个快速生长的肿瘤直径达到2.5 - 3.5厘米。研究发现原发肿瘤和异种移植瘤的组织学之间存在高度相关性。我们得出结论，裸鼠可作为此类研究的动物模型，或用于确定移植肿瘤对细胞抑制药物、类固醇激素和辐射的敏感性。
