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人乳腺癌原位转移移植裸鼠模型

A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer.

作者信息

Fu X, Le P, Hoffman R M

机构信息

AntiCancer Inc., San Diego, CA 92110.

出版信息

Anticancer Res. 1993 Jul-Aug;13(4):901-4.

PMID:8352558
Abstract

We report here the development of an orthotopic-transplant model of human patient breast cancer in nude mice. Histologically-intact patient breast tumor tissue was transplanted as intact tissue to the mammary fat pad of nude mice where the tumor tissue grew extensively and metastasized to the lung. This is the first orthotopic-transplant metastatic model of human breast cancer. The potential clinical and basic-science uses of the model are discussed.

摘要

我们在此报告一种人乳腺癌原位移植模型在裸鼠中的建立。组织学完整的患者乳腺肿瘤组织作为完整组织移植到裸鼠的乳腺脂肪垫，肿瘤组织在那里广泛生长并转移至肺部。这是首个乳腺癌原位移植转移模型。本文还讨论了该模型在临床和基础科学方面的潜在用途。

相似文献

1
A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer.人乳腺癌原位转移移植裸鼠模型
Anticancer Res. 1993 Jul-Aug;13(4):901-4.
2
A new patient-like metastatic model of human small-cell lung cancer constructed orthotopically with intact tissue via thoracotomy in nude mice.一种通过裸鼠开胸手术原位构建的、具有完整组织的新型人小细胞肺癌患者样转移模型。
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A patient-like metastasizing model of human lung adenocarcinoma constructed via thoracotomy in nude mice.通过裸鼠开胸手术构建的人肺腺癌患者样转移模型。
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Cancer seed and soil can be highly selective: human-patient colon tumor lung metastasis grows in nude mouse lung but not colon or subcutis.癌种与土壤具有高度选择性：人类患者的结肠肿瘤肺转移灶在裸鼠肺中生长，但不在结肠或皮下生长。
Anticancer Res. 1995 May-Jun;15(3):795-8.
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Metastatic models of human cancer xenografted in the nude mouse: the importance of orthotopic transplantation.裸鼠异种移植人癌转移模型：原位移植的重要性。
J Cell Biochem. 1994 Sep;56(1):4-8. doi: 10.1002/jcb.240560103.
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Human breast carcinoma xenografts in nude mice.裸鼠体内的人乳腺癌异种移植瘤。
Chin Med J (Engl). 2002 Feb;115(2):222-6.
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Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens.通过原位移植组织学完整的患者标本在裸鼠中构建的人卵巢癌转移模型。
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[A study of human breast carcinoma xenografts in nude mice].[裸鼠人乳腺癌异种移植研究]
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[Nude mouse model of human gastric carcinoma metastasis constructed by orthotopic transplantation using organism glue paste technique].[应用生物胶粘贴技术原位移植构建人胃癌转移裸鼠模型]
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Orthotopic and metastatic tumour models in preclinical cancer research.
临床前癌症研究中的原位和转移瘤模型。
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Non-invasive Fluorescence Imaging of Breast Cancer Metastasis to the Brain in an Orthotopic Nude-mouse Model With Very-narrow-band-width Laser Excitation of Red Fluorescent Protein Resulting in an Ultra-bright Signal Without Skin Autofluorescence.利用近红外窄带宽激光激发红色荧光蛋白进行非侵入式荧光脑转移瘤成像，在避免皮肤自发荧光的情况下，获得超亮信号的裸鼠原位模型。
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