用同源甲状腺微粒体诱导兔慢性甲状腺炎。
Chronic thyroiditis in the rabbit induced with homologous thyroid microsomes.
作者信息
Mangkornkanok M, Markowitz A S, Battifora H A
出版信息
Science. 1972 Oct 20;178(4058):316-8. doi: 10.1126/science.178.4058.316.
PMID:4562254
Abstract
Rabbits immunized with freshly isolated homologous thyroid microsomes in complete Freund's adjuvant developed a severe chronic thyroiditis with the concomitant production of antimicrosomal antibodies. The antibody response was measured by indirect immunofluorescence and complement fixation, employing isolated microsomes as the antigen. Microsomes but not thyroglobulin absorbed out the immunologic activity of the rabbit serum.
摘要
用新鲜分离的同源甲状腺微粒体在完全弗氏佐剂中免疫的兔子发生了严重的慢性甲状腺炎，并伴有抗微粒体抗体的产生。抗体反应通过间接免疫荧光和补体结合法进行测定，使用分离的微粒体作为抗原。微粒体能吸收兔血清的免疫活性，而甲状腺球蛋白则不能。
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