小鼠甲状腺炎。3. 同基因和异基因甲状腺抗原对疾病诱导的影响。
Murine thyroiditis. 3. Influence of syngeneic and allogeneic thyroid antigen on induction of the disease.
作者信息
Vladutiu A O, Rose N R
出版信息
Clin Exp Immunol. 1972 Jun;11(2):245-54.
Experimental autoimmune thyroiditis, characterized by thyroid antibodies (precipitating, haemagglutinating and complement fixing) and infiltration of the gland with mononuclear cells, was induced in inbred and randomly bred strains of mice, using thyroid extract from the same (syngeneic) or different (allogeneic) strains emulsified in sonicated Freund's complete adjuvant. The syngeneic antigen was much less efficacious than the allogeneic in inducing thyroid antibody and lesions. The subcutaneous route was more effective than intradermal immunization and pertussis vaccine decreased the incidence of the disease. Thyroid lesions and antibodies were found 9–14 days after immunization and were still present 3 months later. Differences, genetically determined, were observed in various inbred strains of mice in the degree of thyroid lesions as well as in the titre of thyroid antibody.
实验性自身免疫性甲状腺炎的特征是存在甲状腺抗体（沉淀、血凝和补体结合）以及甲状腺有单核细胞浸润。通过将来自同系（同基因）或不同系（异基因）品系的甲状腺提取物乳化于超声处理的弗氏完全佐剂中，在近交系和随机繁殖系小鼠中诱导出了这种疾病。同基因抗原在诱导甲状腺抗体和病变方面比异基因抗原的效果要差得多。皮下途径比皮内免疫更有效，百日咳疫苗可降低该病的发病率。免疫后9至14天可发现甲状腺病变和抗体，3个月后这些病变和抗体依然存在。在不同的近交系小鼠中观察到了由基因决定的差异，这些差异体现在甲状腺病变程度以及甲状腺抗体滴度方面。
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