Sinclair R A
Br Med J. 1972 Oct 7;4(5831):15-6. doi: 10.1136/bmj.4.5831.15.
Sex chromatin counts performed on the endothelial cells of 40 human kidneys transplanted to recipients of the opposite sex showed that the donor endothelium had persisted except in three poorly functioning and severely damaged grafts. In these a high proportion of the endothelial cells in peritubular capillaries and veins were derived from the host. Endothelial repopulation of organ allografts probably occurs only after severe tissue injury, and it cannot explain the phenomenon of graft adaptation. Repopulated endothelium may be derived from circulating cells.
对移植到异性受者体内的40个人类肾脏的内皮细胞进行性染色质计数显示，除了3个功能不佳且严重受损的移植物外，供体内皮细胞持续存在。在这些移植物中，肾小管周围毛细血管和静脉中的内皮细胞有很大比例来源于宿主。器官同种异体移植物的内皮细胞再填充可能仅在严重组织损伤后发生，并且它无法解释移植物适应现象。再填充的内皮细胞可能来源于循环细胞。
