LoGiudice J A, Geenen J E, Hogan W J, Dodds W J
Dig Dis Sci. 1979 Jun;24(6):455-8. doi: 10.1007/BF01299827.
The morphine-Prostigmin test (MPT) has been advocated as a diagnostic test for identifying patients with papillary stenosis. We studied 14 patients referred for possible papillary stenosis with the MPT and ERCP sphincter of Oddi manometry. The response to the MPT (symptoms, serum amylase/lipase values) was evaluated by multiple criteria. The MPT was also done on 6 volunteer control subjects. Operative evaluation of the sphincter of Oddi was obtained in 8 of the 14 patients. There was no correlation between the results of the MPT and ERCP manometry or operative findings. There was good correlation, however, between ERCP manometric findings and operative assessment of the sphincter of Oddi. Fifty percent of the volunteer subjects had a significantly positive enzyme response to the MPT. In our experience the MPT does not reliably detect patients with papillary stenosis.
吗啡-新斯的明试验（MPT）一直被推荐作为一种用于识别乳头狭窄患者的诊断试验。我们对14例因可能存在乳头狭窄而接受MPT和内镜逆行胰胆管造影术（ERCP）下Oddi括约肌测压的患者进行了研究。通过多种标准评估对MPT的反应（症状、血清淀粉酶/脂肪酶值）。还对6名志愿者对照者进行了MPT。14例患者中有8例接受了Oddi括约肌的手术评估。MPT结果与ERCP测压或手术结果之间无相关性。然而，ERCP测压结果与Oddi括约肌的手术评估之间存在良好的相关性。50%的志愿者对MPT有明显的阳性酶反应。根据我们的经验，MPT不能可靠地检测出乳头狭窄患者。
