Chiocchio S R, Cannata M A, Funes J R, Tramezzani J H
Endocrinology. 1979 Aug;105(2):544-7. doi: 10.1210/endo-105-2-544.
Dopamine (DA) was measured in the anterior lobe of the pituitary and median eminence from lactating rats. The effect of pup separation and suckling was studied in order to correlate changes in DA levels with changes in serum PRL. In lactating rats separated from their pups, low levels of circulating PRL were found at 2,4, and 8 h. DA levels in the median eminence showed a decline at 2h; at 4 and 8 h of separation, a significant increase was observed. In the pars distalis, the concentration of DA increased with the length of the nonsuckling interval. Suckling induced a rapid rise in serum PRL levels in rats that were separated from their pups 4 h earlier. Under these conditions, a significant decrease in DA levels in the median eminence and pars distalis was observed as early as 5 min after the onset of suckling; at 30 min, the DA levels were still low. In the situations studied (suckling and pup separation), a negative correlation between serum PRL and DA levels in both the median eminence and pars distalis was always found.
测定了泌乳大鼠垂体前叶和正中隆起中的多巴胺（DA）。研究了幼崽分离和哺乳的影响，以便将DA水平的变化与血清催乳素（PRL）的变化联系起来。在与幼崽分离的泌乳大鼠中，在2小时、4小时和8小时时发现循环PRL水平较低。正中隆起中的DA水平在2小时时下降；在分离4小时和8小时时，观察到显著升高。在远侧部，DA的浓度随着非哺乳间隔时间的延长而增加。哺乳使4小时前与幼崽分离的大鼠血清PRL水平迅速升高。在这些条件下，早在哺乳开始后5分钟，就观察到正中隆起和远侧部的DA水平显著下降；在30分钟时，DA水平仍然很低。在所研究的情况（哺乳和幼崽分离）中，始终发现正中隆起和远侧部的血清PRL与DA水平之间呈负相关。
