Chiocchio S R, Chafuen S, Tramezzani J H
Endocrinology. 1980 Jun;106(6):1682-5. doi: 10.1210/endo-106-6-1682.
In order to study whether changes in adenohypophysial dopamine are only related to PRL release or also to the variation of LH or FSH, dopamine (DA) in the pars distalis was measured during the estrous cycle and after castration of both male and female rats. Catecholamines were assayed using a highly sensitive radioenzymatic method. Dopamine and norepinephrine were also measured in the median eminence of the same rats. Adenohypophysial dopamine fluctuates during the estrous cycle, reaching its lowest levels on the afternoon of proestrus. Ovariectomy increases the DA content of the anterior lobe and estrogens reverse this effect. Orchidectomy does not change the amount of DA in the anterior pituitary. DA concentration in the median eminence parallels the changes observed in the pars distalis. We conclude that anterior pituitary dopamine concentration is closely related to PRL release and is not associated with changes in the release of LH or FSH.
为了研究腺垂体多巴胺的变化是否仅与催乳素释放有关，还是也与促黄体生成素或促卵泡激素的变化有关，在雌性和雄性大鼠的发情周期以及去势后，测量了远侧部的多巴胺（DA）。使用高灵敏度的放射酶法测定儿茶酚胺。还测量了同一批大鼠正中隆起中的多巴胺和去甲肾上腺素。腺垂体多巴胺在发情周期中波动，在动情前期下午达到最低水平。卵巢切除增加了前叶的多巴胺含量，而雌激素可逆转这种作用。睾丸切除不改变垂体前叶多巴胺的含量。正中隆起中的多巴胺浓度与远侧部观察到的变化平行。我们得出结论，垂体前叶多巴胺浓度与催乳素释放密切相关，与促黄体生成素或促卵泡激素释放的变化无关。
