一种减毒委内瑞拉马脑炎疫苗（TC-83株）的现场研究。
Field studies of an attenuated Venezuelan equine encephalomyelitis vaccine (strain TC-83).
作者信息
Eddy G A, Martin D H, Reeves W C, Johnson K M
出版信息
Infect Immun. 1972 Feb;5(2):160-3. doi: 10.1128/iai.5.2.160-163.1972.
Abstract
A series of field studies using strain TC-83 attenuated Venezuelan equine encephalomyelitis vaccine in horses was made to determine the rate of seroconversions, the postvaccination viremia, and the possibility of adverse reactions to the vaccine. The rate of seroconversions varied from 50% in one study to 91 and 100% in two others. The highest level of viremia measured was 7 x 10(3) to 8 x 10(3) plaqueforming units per ml. No adverse reactions to the vaccine were observed in any horses, including 42 pregnant mares and their resulting foals.
摘要
开展了一系列针对马匹使用TC-83株减毒委内瑞拉马脑炎疫苗的现场研究，以确定血清转化率、疫苗接种后的病毒血症以及疫苗不良反应的可能性。血清转化率在一项研究中为50%，在另外两项研究中分别为91%和100%。测得的最高病毒血症水平为每毫升7×10³至8×10³空斑形成单位。在任何马匹中均未观察到疫苗不良反应，包括42匹怀孕母马及其产下的驹。
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