重组痘苗病毒/委内瑞拉马脑炎（VEE）病毒可保护小鼠免受外周VEE病毒攻击。
Recombinant vaccinia virus/Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge.
作者信息
Kinney R M, Esposito J J, Mathews J H, Johnson B J, Roehrig J T, Barrett A D, Trent D W
机构信息
Division of Vector-Borne Viral Diseases, Centers for Disease Control, Fort Collins, Colorado 80522-2087.
出版信息
J Virol. 1988 Dec;62(12):4697-702. doi: 10.1128/JVI.62.12.4697-4702.1988.
Abstract
Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus.
摘要
用表达委内瑞拉马脑炎（VEE）病毒衣壳蛋白以及糖蛋白E1和E2的重组痘苗病毒（VACC）免疫的小鼠，或用减毒的VEE TC - 83病毒疫苗免疫的小鼠，产生了VEE特异性中和抗体，并在腹腔内接受包括特立尼达驴（1AB亚型）、P676（1C亚型）、3880（1D亚型）和大沼泽地（2亚型）等强毒VEE病毒株攻击后存活下来。然而，与用TC - 83病毒免疫不同，用重组VACC/VEE病毒免疫并不能保护小鼠免受VEE特立尼达驴病毒的鼻内攻击。这些结果表明，重组VACC/VEE病毒是针对有蚊媒传播VEE疾病风险的马和人的候选疫苗，但不适用于有意外暴露于VEE病毒气溶胶感染风险的实验室工作人员。
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本文引用的文献
1
TWO HUMAN CASES OF LABORATORY INFECTION WITH MUCAMBO VIRUS.
Am J Trop Med Hyg. 1965 May;14:475-8.
2
USE OF AN ATTENUATED STRAIN OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS FOR IMMUNIZATION IN MAN.
Am J Trop Med Hyg. 1963 Jul;12:597-603. doi: 10.4269/ajtmh.1963.12.597.
3
Immunization of burros with living Venezuelan equine encephalomyelitis virus.
Am J Hyg. 1962 May;75:351-62. doi: 10.1093/oxfordjournals.aje.a120257.
4
Venezuelan equine encephalomyelitis in horses.
Am J Hyg. 1956 May;63(3):274-87. doi: 10.1093/oxfordjournals.aje.a119811.
5
Venezuelan equine encephalomyelitis due to vaccination in man.
J Am Med Assoc. 1954 Aug 21;155(17):1473-6. doi: 10.1001/jama.1954.03690350015005.
6
Comparative immunological and biochemical analyses of viruses in the Venezuelan equine encephalitis complex.
J Gen Virol. 1983 Jan;64 (Pt 1):135-47. doi: 10.1099/0022-1317-64-1-135.
7
Protective efficacies of live attenuated and formaldehyde-inactivated Venezuelan equine encephalitis virus vaccines against aerosol challenge in hamsters.
J Clin Microbiol. 1984 Mar;19(3):429-31. doi: 10.1128/jcm.19.3.429-431.1984.
8
Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters.
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7155-9. doi: 10.1073/pnas.80.23.7155.
9
Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies.
Infect Immun. 1984 Feb;43(2):756-8. doi: 10.1128/iai.43.2.756-758.1984.
10
The preparation of orthopoxvirus DNA.
J Virol Methods. 1981 Feb;2(3):175-9. doi: 10.1016/0166-0934(81)90036-7.
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