Cole F E, Pedersen C E, Robinson D M
Appl Microbiol. 1972 Oct;24(4):604-8. doi: 10.1128/am.24.4.604-608.1972.
The rapid onset and persistence of homologous and heterologous protection induced by attenuated Venezuelan equine encephalomyelitis (VEE) vaccine (TC-83) were studied in the hamster, by using challenge response as the index of protection. At 8 hr postvaccination with 10(3) median immunizing doses of TC-83 vaccine, 15 to 20% of animals were protected against challenge with VEE virus as well as Eastern and Western equine encephalomyelitis viruses. The percentage of protection increased with time postvaccination until 80 to 90% homologous and heterologous protection was achieved by 18 hr postvaccination. Temporal studies indicated that early protection (days 1 to 6) correlated with vaccine viremia, and that the percentage of protection against heterologous challenge decreased with the cessation of viremia. Data are presented to indicate that the early protection phenomenon is one of interference, since little or no replication of a challenge virus occurred when it was administered during the vaccine viremia stage.
以攻击反应作为保护指标，在仓鼠中研究了减毒委内瑞拉马脑炎（VEE）疫苗（TC - 83）诱导的同源和异源保护的快速起效及持续情况。在用10³个TC - 83疫苗免疫剂量中位数进行疫苗接种后8小时，15%至20%的动物受到保护，可抵御VEE病毒以及东部和西部马脑炎病毒的攻击。保护百分比随接种后时间增加，直到接种后18小时实现80%至90%的同源和异源保护。时间研究表明，早期保护（第1至6天）与疫苗病毒血症相关，并且随着病毒血症停止，抵御异源攻击的保护百分比下降。数据表明早期保护现象是一种干扰现象，因为当在疫苗病毒血症阶段接种攻击病毒时，该病毒很少或不发生复制。
