Zarkower A, Morges W
Infect Immun. 1972 Jun;5(6):915-20. doi: 10.1128/iai.5.6.915-920.1972.
The immune response in mice to antigens given by intraperitoneal, intravenous, and inhalation routes was compared in control and carbon-dust exposed mice. The most pronounced effect, a decrease in antibody-forming cells and serum agglutinin titers, was observed when the carbon-treated animals were immunized with antigens in the form of aerosol. Similar results were obtained when the antigens were administered by intravenous or intraperitoneal route. In contrast 4-days of pre-exposure to carbon dust increased the number of antibody-forming cells in the mediastinal lymph nodes. However, this effect was transient and was not significant when the carbon pre-exposure was continued for 15 days.
在对照小鼠和接触碳尘的小鼠中，比较了经腹腔、静脉和吸入途径给予抗原后小鼠的免疫反应。当用气溶胶形式的抗原免疫经碳处理的动物时，观察到最显著的效应，即抗体形成细胞和血清凝集素滴度降低。当通过静脉或腹腔途径给予抗原时，也获得了类似的结果。相反，预先接触碳尘4天可增加纵隔淋巴结中抗体形成细胞的数量。然而，这种效应是短暂的，当碳预先接触持续15天时，这种效应并不显著。
