Anderson T H, Roethle J, Auerbach R
J Exp Med. 1972 Dec 1;136(6):1666-71. doi: 10.1084/jem.136.6.1666.
Adult mice injected with a sheep red blood cell hemolysate supernatant fraction were found to have a severely reduced responsiveness to subsequent immunization with sheep red blood cells. The induced unresponsiveness was found to be specific, as tested by reciprocal experiments involving horse and sheep erythrocyte preparations. The tolerogenic material did not appear to be immunogenic.
给成年小鼠注射绵羊红细胞溶血产物上清液组分后，发现其对随后用绵羊红细胞进行免疫的反应性严重降低。通过涉及马和绵羊红细胞制剂的相互实验测试发现，诱导的无反应性具有特异性。致耐受性物质似乎没有免疫原性。
