Kingsley D P, Goldberg B, Abrahams C, Meyers A J, Furman K I, Cohen I
Br Med J. 1972 Dec 16;4(5841):656-9. doi: 10.1136/bmj.4.5841.656.
Sixty-six patients were seen from January 1963 to December 1970 in whom a diagnosis of analgesic nephropathy was made. The ratio of women to men was 2.7:1 and women presented at an earlier age. Over 60% of patients had or developed urinary tract infection and over one-third presented with serum urea levels over 300 mg/100 ml. Hypertension was present in 60% of patients and almost 20% had a history of peptic ulcer; hysterectomy had been done in 35% of the women. Most patients improved initially but more than half of those followed up died within five years of presentation. A direct relation was found between prognosis and the degree of functional renal impairment at presentation. Hypertension appeared to have an adverse effect on prognosis but no relation of prognosis to papillary necrosis, infection, or surgical procedures was found.
1963年1月至1970年12月期间，共诊治了66例诊断为止痛剂肾病的患者。女性与男性的比例为2.7:1，且女性发病年龄较早。超过60%的患者曾患或发生过尿路感染，超过三分之一的患者血清尿素水平超过300mg/100ml。60%的患者患有高血压，近20%有消化性溃疡病史；35%的女性接受过子宫切除术。大多数患者最初病情有所改善，但超过一半的随访患者在就诊后五年内死亡。发现预后与就诊时肾功能损害程度直接相关。高血压似乎对预后有不良影响，但未发现预后与乳头坏死、感染或外科手术之间存在关联。
