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Identification of a reactive cysteine residue at the glutamine binding site of carbamyl phosphate synthetase.

作者信息

Pinkus L M, Meister A

出版信息

J Biol Chem. 1972 Oct 10;247(19):6119-27.

PMID:4568602
Abstract
摘要

相似文献

1
Identification of a reactive cysteine residue at the glutamine binding site of carbamyl phosphate synthetase.在氨甲酰磷酸合成酶谷氨酰胺结合位点鉴定出一个反应性半胱氨酸残基。
J Biol Chem. 1972 Oct 10;247(19):6119-27.
2
Characterization of the reactive sulfhydryl groups in carbamyl phosphate synthetase of Escherichia coli.
Biochemistry. 1971 Nov 23;10(24):4562-9. doi: 10.1021/bi00800a034.
3
Interaction of Escherichia coli carbamyl phosphate synthetase with glutamine.大肠杆菌氨甲酰磷酸合成酶与谷氨酰胺的相互作用。
Biochemistry. 1973 May 22;12(11):2061-6. doi: 10.1021/bi00735a006.
4
Inhibition by dithiothreitol of the utilization of glutamine by carbamyl phosphate synthetase. Evidence for formation of hydrogen peroxide.二硫苏糖醇对氨甲酰磷酸合成酶利用谷氨酰胺的抑制作用。过氧化氢形成的证据。
J Biol Chem. 1974 Mar 25;249(6):1915-21.
5
Reversible dissociation of the monomer of glutamine-dependent carbamyl phosphate synthetase into catalytically active heavy and light subunits.谷氨酰胺依赖性氨甲酰磷酸合成酶单体可逆解离为具有催化活性的重链和轻链亚基。
J Biol Chem. 1974 Jan 25;249(2):492-9.
6
Effect of allosteric effectors and adenosine triphosphate on the aggregation and rate of inhibition by N-ethylmaleimide of carbamyl phosphate synthetase of Escherichia coli.
Biochemistry. 1970 Jan 6;9(1):171-8. doi: 10.1021/bi00803a022.
7
Self-association and allosteric properties of glutamine-dependent carbamyl phosphate synthetase. Reversible dissociation to monomeric species.谷氨酰胺依赖性氨甲酰磷酸合成酶的自缔合和别构性质。可逆解离为单体形式。
J Biol Chem. 1974 Jan 25;249(2):482-9.
8
Action patterns of feedback modifiers on equilibrium exchanges and applications to glutamine synthetase (Escherichia coli W).反馈调节剂对平衡交换的作用模式及其在谷氨酰胺合成酶(大肠杆菌W)中的应用
J Biol Chem. 1972 Feb 25;247(4):993-1000.
9
Effect of ornithine, IMP, and UMP on carbamyl phosphate synthetase from Escherichia coli.鸟氨酸、肌苷酸和尿苷酸对大肠杆菌氨甲酰磷酸合成酶的影响。
Biochem Biophys Res Commun. 1968 Sep 30;32(6):928-34. doi: 10.1016/0006-291x(68)90116-2.
10
Functional arginyl residues as ATP binding sites of glutamine synthetase and carbamyl phosphate synthetase.作为谷氨酰胺合成酶和氨甲酰磷酸合成酶ATP结合位点的功能性精氨酰残基。
Proc Natl Acad Sci U S A. 1975 Jul;72(7):2616-20. doi: 10.1073/pnas.72.7.2616.

引用本文的文献

1
Regulation of carbamoylphosphate synthesis in Escherichia coli: an amazing metabolite at the crossroad of arginine and pyrimidine biosynthesis.大肠杆菌中氨甲酰磷酸合成的调控:精氨酸和嘧啶生物合成交汇点处的神奇代谢物。
Amino Acids. 2018 Dec;50(12):1647-1661. doi: 10.1007/s00726-018-2654-z. Epub 2018 Sep 20.
2
Inhibition by glutamate of phosphate-dependent glutaminase of rat kidney.谷氨酸对大鼠肾脏磷酸依赖性谷氨酰胺酶的抑制作用。
Biochem J. 1982 Dec 1;207(3):561-6. doi: 10.1042/bj2070561.
3
Observations on the pH dependence of the glutaminase activity of a glutamine amidotransferase, carbamylphosphate synthetase.
谷氨酰胺酰胺转移酶(氨甲酰磷酸合成酶)谷氨酰胺酶活性的pH依赖性观察
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2717-21. doi: 10.1073/pnas.70.10.2717.
4
Glutamine-binding subunit of glutamate synthase and partial reactions catalyzed by this glutamine amidotransferase.谷氨酸合酶的谷氨酰胺结合亚基以及该谷氨酰胺氨基转移酶催化的部分反应。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4607-11. doi: 10.1073/pnas.71.11.4607.
5
Physiology and genetics of carbamoylphosphate synthesis in Escherichia coli K12.大肠杆菌K12中氨甲酰磷酸合成的生理学与遗传学
Mol Gen Genet. 1974;133(4):299-316. doi: 10.1007/BF00332706.
6
Biosynthesis and metabolism of arginine in bacteria.细菌中精氨酸的生物合成与代谢
Microbiol Rev. 1986 Sep;50(3):314-52. doi: 10.1128/mr.50.3.314-352.1986.
7
Identification of a highly reactive threonine residue at the active site of gamma-glutamyl transpeptidase.γ-谷氨酰转肽酶活性位点高反应性苏氨酸残基的鉴定
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1706-9. doi: 10.1073/pnas.87.5.1706.
8
Inhibition of amino acid transport into lymphoid cells by the glutamine analog L-2-amino-4-oxo-5-chloropentanoate.谷氨酰胺类似物L-2-氨基-4-氧代-5-氯戊酸对氨基酸转运至淋巴细胞的抑制作用。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):4932-5. doi: 10.1073/pnas.76.10.4932.
9
Structure-function relationships in the arginine pathway carbamoylphosphate synthase of Saccharomyces cerevisiae.酿酒酵母精氨酸途径中氨甲酰磷酸合酶的结构-功能关系
J Bacteriol. 1978 Apr;134(1):167-76. doi: 10.1128/jb.134.1.167-176.1978.
10
Affinity labeling of gamma-glutamyl transpeptidase and location of the gamma-glutamyl binding site on the light subunit.γ-谷氨酰转肽酶的亲和标记及γ-谷氨酰结合位点在轻亚基上的定位
Proc Natl Acad Sci U S A. 1977 Mar;74(3):931-5. doi: 10.1073/pnas.74.3.931.