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A new method for testing genetically active metabolites. Urinary assay with cyclophosphamide (endoxan, cytoxan) and Saccharomyces cerevisiae.

作者信息

Siebert D

出版信息

Mutat Res. 1973 Mar;17(3):307-14. doi: 10.1016/0027-5107(73)90002-x.

DOI:10.1016/0027-5107(73)90002-x
PMID:4569494
Abstract
摘要

相似文献

1
A new method for testing genetically active metabolites. Urinary assay with cyclophosphamide (endoxan, cytoxan) and Saccharomyces cerevisiae.
Mutat Res. 1973 Mar;17(3):307-14. doi: 10.1016/0027-5107(73)90002-x.
2
Host-mediated assay with yeast and rats using probenecid (Benemid) to block the renal tubular excretion of cyclophosphamide metabolites.
Mutat Res. 1975 Apr;28(1):57-61. doi: 10.1016/0027-5107(75)90314-0.
3
Cyclophosphamide: pilot study of genetically active metabolites in the urine of a treated human patient. Induction of mitotic gene conversions in yeast.
Mutat Res. 1973 Jul;19(1):65-72. doi: 10.1016/0027-5107(73)90114-0.
4
Genetic activity of metabolites in the ascitic fluid and in the urine of a human patient treated with cyclophosphamide: induction of mitotic gene conversion in Saccharomyces cerevisiae.
Mutat Res. 1973 Oct;21(5):257-62.
5
Development of host-mediated mutagenicity tests. I. Differential response of yeast cells injected into testes of rats and peritoneum of mice and rats to mutagens.
Mutat Res. 1974 Feb;26(1):29-36. doi: 10.1016/s0027-5107(74)80067-9.
6
Genetic effects induced in Saccharomyces cerevisiae by cyclophosphamide in vitro without liver enzyme preparations.体外无肝酶制剂情况下环磷酰胺对酿酒酵母诱导的遗传效应。
Mutat Res. 1976 Nov;37(2-3):201-12. doi: 10.1016/0027-5107(76)90034-8.
7
Mutation and recombination experiments with yeast as prescreening tests for carcinogenic effects?以酵母进行突变和重组实验作为致癌作用的预筛选试验？
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;81(3-4):333-46. doi: 10.1007/BF00305033.
8
Comparison of the genetic activity of cyclophosphamide, ifosfamide and trofosfamide in host-mediated assays with the gene conversion system of yeast.在宿主介导的实验中，使用酵母基因转换系统比较环磷酰胺、异环磷酰胺和曲磷胺的遗传活性。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;81(3-4):261-7. doi: 10.1007/BF00305028.
9
[A new host mediated assay (urine assay) for the determination of mutagenic drugs using Saccharomyces cerevisiae].
Naturwissenschaften. 1971 Nov;58(11):568. doi: 10.1007/BF00598725.
10
Genetic effects of herbicides: induction of mitotic gene conversion in Saccharomyces cerevisiae.除草剂的遗传效应：酿酒酵母中有丝分裂基因转换的诱导
Mutat Res. 1974 Feb;22(2):111-20. doi: 10.1016/0027-5107(74)90090-6.

引用本文的文献

1
Polycyclic aromatic hydrocarbons and possible metabolites: convertogenic activity in yeast and tumor initiating activity in mouse skin.多环芳烃及其可能的代谢产物：在酵母中的转化活性及在小鼠皮肤中的肿瘤起始活性。
J Cancer Res Clin Oncol. 1981;102(2):127-39. doi: 10.1007/BF00410664.
2
Test systems for mutagenicity screening of environmental chemicals and their relevance for the evaluation of genetic hazards to man.环境化学物质致突变性筛查的测试系统及其与评估对人类遗传危害的相关性。
J Cancer Res Clin Oncol. 1981;99(1-2):87-102. doi: 10.1007/BF00412446.
3
The place of the host-mediated assay.
宿主介导试验的地位。
Arch Toxicol. 1980 Nov;46(1-2):111-21. doi: 10.1007/BF00361250.
4
Mutagens in urine of carbon electrode workers.
Int Arch Occup Environ Health. 1982;50(4):387-95. doi: 10.1007/BF00377835.
5
A simple method for the detection of mutagens in urine: studies with the carcinogen 2-acetylaminofluorene.一种检测尿液中诱变剂的简单方法：用致癌物2-乙酰氨基芴进行的研究。
Proc Natl Acad Sci U S A. 1974 Mar;71(3):737-41. doi: 10.1073/pnas.71.3.737.
6
New developments in mutagenicity screening techniques with yeast.酵母致突变性筛选技术的新进展。
Environ Health Perspect. 1973 Dec;6:83-96. doi: 10.1289/ehp.730683.
7
Mutation and recombination experiments with yeast as prescreening tests for carcinogenic effects?以酵母进行突变和重组实验作为致癌作用的预筛选试验？
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;81(3-4):333-46. doi: 10.1007/BF00305033.
8
Comparison of the genetic activity of cyclophosphamide, ifosfamide and trofosfamide in host-mediated assays with the gene conversion system of yeast.在宿主介导的实验中，使用酵母基因转换系统比较环磷酰胺、异环磷酰胺和曲磷胺的遗传活性。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;81(3-4):261-7. doi: 10.1007/BF00305028.
9
Mutagenic activity of cyclophosphamide, ifosfamide, and trofosfamide in different genes of escherichia coli and salmonella typhimurium after biotransformation through extracts of rodent liver.经啮齿动物肝脏提取物生物转化后，环磷酰胺、异环磷酰胺和曲磷胺在大肠杆菌和鼠伤寒沙门氏菌不同基因中的诱变活性。
Arch Toxicol. 1975;33(3):225-40. doi: 10.1007/BF00311275.
10
Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide.氯乙醛的致突变性，氯乙醛是1,2 - 二氯乙烷（二氯化乙烯）、氯乙醇（氯乙醇）、氯乙烯和环磷酰胺的一种可能代谢产物。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3190-3. doi: 10.1073/pnas.72.8.3190.