鼠伤寒沙门氏菌中组成型半乳糖通透酶突变体的特性分析。
Characterization of constitutive galactose permease mutants in Salmonella typhimurium.
作者信息
Saier M H, Bromberg F G, Roseman S
出版信息
J Bacteriol. 1973 Jan;113(1):512-4. doi: 10.1128/jb.113.1.512-514.1973.
Abstract
Salmonella typhimurium strains, lacking both enzyme I and the phosphocarrier protein, HPr, of the phosphoenolpyruvate-sugar phosphotransferase system, cannot transport or metabolize glucose and other sugar substrates of this enzyme system. Mutants which regain the ability to specifically utilize glucose were found to constitutively synthesize a galactose permease by virtue of a mutation in the galR gene. This permease, shown to be an active transport system, does not require HPr or enzyme I for activity.
摘要
鼠伤寒沙门氏菌菌株缺乏磷酸烯醇丙酮酸 - 糖磷酸转移酶系统的酶Ⅰ和磷酸载体蛋白HPr，无法转运或代谢该酶系统的葡萄糖及其他糖类底物。通过galR基因突变，重新获得特异性利用葡萄糖能力的突变体被发现可组成型合成半乳糖通透酶。这种通透酶被证明是一种主动运输系统，其活性不需要HPr或酶Ⅰ。
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