磷酸转移酶系统的乳糖酶II参与化脓性链球菌游离半乳糖苷的快速排出。
Involvement of lactose enzyme II of the phosphotransferase system in rapid expulsion of free galactosides from Streptococcus pyogenes.
作者信息
Reizer J, Saier M H
出版信息
J Bacteriol. 1983 Oct;156(1):236-42. doi: 10.1128/jb.156.1.236-242.1983.
Abstract
Streptococcus pyogenes accumulated thiomethyl-beta-galactoside as the 6-phosphate ester due to the action of the phosphoenolpyruvate:lactose phosphotransferase system. Subsequent addition of glucose resulted in rapid efflux of the free galactoside after intracellular dephosphorylation (inducer expulsion). Efflux was shown to occur in the apparent absence of the galactose permease, but was inhibited by substrate analogs of the lactose enzyme II and could not be demonstrated in a mutant of S. lactis ML3 which lacked this enzyme. The results suggest that the enzymes II of the phosphotransferase system can catalyze the rapid efflux of free sugar under appropriate physiological conditions.
摘要
由于磷酸烯醇丙酮酸
乳糖磷酸转移酶系统的作用，化脓性链球菌积累硫代甲基-β-半乳糖苷作为6-磷酸酯。随后添加葡萄糖导致细胞内去磷酸化后游离半乳糖苷迅速流出（诱导物排出）。结果表明，流出在明显缺乏半乳糖通透酶的情况下发生，但受到乳糖酶II底物类似物的抑制，并且在缺乏该酶的乳酸乳球菌ML3突变体中无法证明。结果表明，磷酸转移酶系统的酶II在适当的生理条件下可以催化游离糖的快速流出。
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