Sparano F, Giaquinto G, Odoardi A, Mercuri M A, Tosti-Croce C, Sulon J, Sciarra F
Horm Res. 1979;10(5):282-8. doi: 10.1159/000179009.
The present study was carried out in 25 hypertensive uremic patients on regular 4 h dialysis, 3 times a week. Plasma 18-hydroxy-11-deoxycorticosterone (18-OH-DOC), aldosterone (PA) and corticosteroids were determined by radioimmunoassay and competitive protein binding technique before and at the end of the 1st, 2nd and 3rd hour of hemodialysis. Plasma 18-HD-DOC was normal before dialysis and did not change significantly during hemodialysis, whereas body fluids and electolytes decreased progressively. No correlation was observed between blood pressure and 18-OH-DOC during dialysis. 18-OH-DOC did not correlate with PA which decreases progressively during hemodialysis and was correlated to plasma corticosteroids only at the 3rd hour of dialysis, probably on account of the enhanced influence of ACTH on the adrenal cortex.
本研究对25例接受常规每周3次、每次4小时透析的高血压尿毒症患者进行。采用放射免疫分析法和竞争性蛋白结合技术，在血液透析前以及透析第1、2、3小时结束时测定血浆18-羟-11-脱氧皮质酮（18-OH-DOC）、醛固酮（PA）和皮质类固醇。透析前血浆18-HD-DOC正常，血液透析期间无显著变化，而体液和电解质逐渐减少。透析期间血压与18-OH-DOC之间未观察到相关性。18-OH-DOC与PA无相关性，PA在血液透析期间逐渐降低，仅在透析第3小时与血浆皮质类固醇相关，这可能是由于促肾上腺皮质激素（ACTH）对肾上腺皮质的影响增强所致。
