Brat S V
Hum Genet. 1979 Apr 17;48(1):73-9. doi: 10.1007/BF00273277.
Sister chromatid exchange (SCE) has been studied in the fibroblasts of five Bloom's syndrome patients, one heterozygote, and two normal individuals. The high frequency of SCE already known in the lymphocytes of Bloom's syndrome was also found in the fibroblasts of all five patients. However, populations with low and high frequency of SCE were not found. In addition, chromosome aberrations appeared with a lower frequency. The cell cycle duration in the Bloom's fibroblasts appeared to be similar to that in the normal cell line, and the difference in the growth pattern appeared to be due to the variation in the mitotic index. The cell cycle lasted about 24 h in at least four of the Bloom's lines studied during the present experiments.
对5名布卢姆综合征患者、1名杂合子和2名正常个体的成纤维细胞进行了姐妹染色单体交换（SCE）研究。布卢姆综合征患者淋巴细胞中已知的高频率SCE在所有5名患者的成纤维细胞中也被发现。然而，未发现SCE频率低和高的群体。此外，染色体畸变出现的频率较低。布卢姆综合征成纤维细胞的细胞周期持续时间似乎与正常细胞系相似，生长模式的差异似乎是由于有丝分裂指数的变化。在本实验研究的至少4个布卢姆综合征细胞系中，细胞周期持续约24小时。
