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IARC Sci Publ (1971). 1979(25):75-9.
The reaction is described of the National Institute for Occupational Safety and Health (NIOSH) in the US to the results of experimental studies which showed that tetrachlorethylene is carcinogenic. Parallels are given with vinyl chloride, which it resembles structurally. The main occupational exposure to trichloroethylene is in the vapour degreasing of metal parts. The machine used for this activity is described, and it is shown that there is a high potential exposure. Possible control measures are outlined. The main evidence for the potential carcinogenicity of trichloroethylene is the occurrence of its epoxide as an intermediate in its metabolism to chloroethanol; species differences have been observed. Epdemiological studies have so far been inconclusive. NIOSH decided that trichloroethylene is potentially carcinogenic in the workplace, but only weakly so. No new standard has been recommended, although a lowering of the present standard is recommended.
美国国家职业安全与健康研究所（NIOSH）对实验研究结果的反应被描述，这些研究表明四氯乙烯具有致癌性。文中将其与结构上与之相似的氯乙烯进行了对比。三氯乙烯的主要职业暴露发生在金属部件的蒸汽脱脂过程中。文中描述了用于该活动的机器，并表明存在高潜在暴露风险。文中概述了可能的控制措施。三氯乙烯潜在致癌性的主要证据是其环氧化物作为其代谢为氯乙醇过程中的中间体的出现；已观察到物种差异。到目前为止，流行病学研究尚无定论。NIOSH认定三氯乙烯在工作场所具有潜在致癌性，但致癌性较弱。尽管建议降低现行标准，但尚未推荐新的标准。
