Goldenberg D M, Pavia R A, Smith L
Department of Pathology, University of Kentucky Medical Center, Lexington 40506.
Cancer Lett. 1977 Mar;2(4-5):195-200. doi: 10.1016/s0304-3835(77)80021-9.
A karyological analysis of the G-banded chromosomes of the serially transplantable GW-39 human colonic carcinoma was undertaken. GW-39 cells harvested from hamsters, nude (athymic) mice and cell cultures from 1972 to 1976 revealed a hypodiploid stemline of 45 human chromosomes, with a consistent loss of a 21-chromosome. No apparent alterations of the near-diploid stemline resulted during long-term xenogeneic propagation of this human cancer line.
对可连续移植的GW - 39人结肠癌的G带染色体进行了核型分析。从仓鼠、裸（无胸腺）小鼠以及1972年至1976年的细胞培养物中收获的GW - 39细胞显示出一个具有45条人类染色体的亚二倍体主干系，始终缺失一条21号染色体。在该人类癌症细胞系的长期异种移植传代过程中，近二倍体主干系未出现明显改变。
