Brown I, Ward H W
Department of Radiotherapy and Clinical Oncology, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, U.K.
Cancer Lett. 1977 Mar;2(4-5):227-32. doi: 10.1016/s0304-3835(77)80026-8.
Tissue analyses and tumour regression studies using the oncolytic antibiotic, adriamycin (14-hydroxydaunomycin), and its DNA complex at adriamycin dosages of 5 mg/kg and 10 mg/kg were made on C3H mice with transplanted mammary adenocarcinoma. Chemical analysis indicated a significantly lower (P < 0.05) uptake of adriamycin into cardiac tissue for the adriamycin-DNA complex. Tumour regression was comparable for both the complex and free adriamycin. Results suggest an advantageous role for the adriamycin DNA complex in the chemotherapy of metastatic breast carcinoma.
使用溶瘤抗生素阿霉素（14-羟基柔红霉素）及其DNA复合物，以5mg/kg和10mg/kg的阿霉素剂量，对移植了乳腺腺癌的C3H小鼠进行了组织分析和肿瘤消退研究。化学分析表明，阿霉素-DNA复合物进入心脏组织的阿霉素摄取量显著较低（P<0.05）。复合物和游离阿霉素的肿瘤消退情况相当。结果表明阿霉素DNA复合物在转移性乳腺癌化疗中具有有利作用。
