Antibody formation in experimental amyloidosis.

In endotoxin-induced amyloidosis of mice it was found that all mouse strains formed antibodies specific for the type of endotoxin injected. In casein-induced amyloidosis, the animals form antibodies to certain components of the casein and most likely to whatever contaminating endotoxin is present. The antibodies formed seemed to be primarily of the IgG 1 subclass. Their appearance in high titer shows a good correlation with the onset of amyloid formation especially in mice given casein. Failure to form amyloid in these experimental models does not seem to be related to failure of antibody formation but may be explained by more effective clearance of immune complexes or other such factors.