Schultz R T
Int Arch Allergy Appl Immunol. 1979;60(1):9-21. doi: 10.1159/000232318.
In endotoxin-induced amyloidosis of mice it was found that all mouse strains formed antibodies specific for the type of endotoxin injected. In casein-induced amyloidosis, the animals form antibodies to certain components of the casein and most likely to whatever contaminating endotoxin is present. The antibodies formed seemed to be primarily of the IgG 1 subclass. Their appearance in high titer shows a good correlation with the onset of amyloid formation especially in mice given casein. Failure to form amyloid in these experimental models does not seem to be related to failure of antibody formation but may be explained by more effective clearance of immune complexes or other such factors.
在内毒素诱导的小鼠淀粉样变性中，发现所有小鼠品系都会形成针对所注射内毒素类型的特异性抗体。在酪蛋白诱导的淀粉样变性中，动物会形成针对酪蛋白某些成分的抗体，并且很可能会形成针对任何存在的污染内毒素的抗体。所形成的抗体似乎主要属于IgG 1亚类。它们的高滴度出现与淀粉样形成的开始呈现出良好的相关性，尤其是在给予酪蛋白的小鼠中。在这些实验模型中未能形成淀粉样蛋白似乎与抗体形成失败无关，而是可能由免疫复合物或其他此类因素的更有效清除来解释。
