实验性淀粉样变性：诱导剂是一种多克隆B细胞激活剂，对其易感性受基因控制。
Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control.
作者信息
Britton S
出版信息
J Exp Med. 1975 Dec 1;142(6):1564-9. doi: 10.1084/jem.142.6.1564.
Abstract
Experimental amyloidosis in mice can be induced by repeated injections of casein. It has now been demonstrated that casein induces strong polyclonal antibody synthesis in mouse B spleen lymphocytes. This effect is much more pronounced in spleen cells from anyloid-susceptible mice (CBA/J) than amyloid-resistant mice (A/J). It is suggested that amyloidosis can be due in some instances to a constant exposure for molecules which induce polyclonal B-cell activation.
摘要
通过反复注射酪蛋白可在小鼠中诱导实验性淀粉样变性。现已证明，酪蛋白能在小鼠B脾淋巴细胞中诱导强烈的多克隆抗体合成。在易患淀粉样变性的小鼠（CBA/J）的脾细胞中，这种效应比抗淀粉样变性的小鼠（A/J）更为明显。有人提出，在某些情况下，淀粉样变性可能是由于持续暴露于诱导多克隆B细胞活化的分子所致。
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