Anderson L G, Tarpley T M, Talal N, Cummings N A, Wolf R O, Schall G L
Clin Exp Immunol. 1973 Mar;13(3):335-42.
In Sjögren's syndrome (SS), the earliest glandular infiltration by lymphoid cells surrounds the salivary ducts, which are also the target of the organ-specific antisalivary duct (ASD) autoantibody found in some patients with this disorder. A sensitizing antigen localized in ductal epithelial cells may elicit both humoral and cellular immune responses. In a study using coded specimens from twenty-five patients with SS and eight with rheumatoid arthritis, sera were tested for ASD, and lip biopsies were graded for the degree of lymphoid infiltration and destruction of labial salivary glands. Significantly less cellular infiltration was found in SS patients who had ASD compared to those who lacked this antibody. In SS, the group of ASD-negative patients had greater gland destruction and more severe xerostomia. The possible role of ASD as a blocking antibody is suggested.
在干燥综合征（SS）中，最早出现的淋巴细胞对腺体的浸润围绕着唾液腺导管，而唾液腺导管也是在部分患有该疾病的患者中发现的器官特异性抗唾液腺导管（ASD）自身抗体的靶标。定位于导管上皮细胞的致敏抗原可能引发体液免疫和细胞免疫反应。在一项对25例干燥综合征患者和8例类风湿性关节炎患者的编码标本进行的研究中，检测了血清中的ASD，并对唇部活检标本的淋巴浸润程度和唇唾液腺的破坏程度进行了分级。与缺乏该抗体的干燥综合征患者相比，有ASD的患者的细胞浸润明显较少。在干燥综合征中，ASD阴性患者组的腺体破坏更严重，口干症状也更严重。这提示了ASD作为一种封闭抗体的可能作用。
