类风湿关节炎患者泪液和唾液分泌受损以及对唾液抗原的细胞免疫反应受损。
Impairment of lachrymal and salivary secretion and cellular immune responses to salivary antigens in rheumatoid arthritis.
作者信息
Sullivan S, Fernandes L, McFarlane I G, Wojcicka B, Eddleston A L, Doniach D, Hamilton E, Williams R
出版信息
Ann Rheum Dis. 1978 Apr;37(2):164-7. doi: 10.1136/ard.37.2.164.
Abstract
During a systematic investigation of 100 unselected outpatients with rheumatoid arthritis, 58 were found to have reduced lachrymal or salivary secretion. No correlation could be detected between the presence or absence of secretory abnormalities and the age or sex of the patient, the presence of nodules or salivary duct antibody, or the occurrence of vasculitis. However, there was a significant correlation between diminished salivary of lachrymal flow and the occurrence of cellular immune responses to a protein fraction of normal human saliva, sensitisation being found in 94% of those with impairment of salivary and lachrymal secretion as compared with 33% of those without.
摘要
在对100名未经挑选的类风湿性关节炎门诊患者进行的系统调查中，发现58人泪液或唾液分泌减少。分泌异常的有无与患者的年龄、性别、结节或唾液导管抗体的存在以及血管炎的发生之间未发现相关性。然而，泪液或唾液分泌减少与对正常人唾液蛋白组分的细胞免疫反应的发生之间存在显著相关性，在唾液和泪液分泌受损的患者中，94%出现致敏，而在未受损患者中这一比例为33%。
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