影响大肠杆菌中葡萄糖酸盐代谢的突变
Mutations affecting gluconate metabolism in Escherichia coli.
作者信息
Nagel de Zwaig R, Zwaig N, Istúriz T, Sánchez R S
出版信息
J Bacteriol. 1973 May;114(2):463-8. doi: 10.1128/jb.114.2.463-468.1973.
Abstract
A mutant of Escherichia coli K-12 that does not ferment gluconate on fermentation plates was isolated and characterized. This mutant, designated M2, shows a long lag for growth on gluconate mineral medium and somewhat reduced levels of high-affinity transport, gluconokinase, and gluconate-6-P dehydrase activities in the log phase of growth. The mutation involved is near malA. Deletion mutants in which malA region was affected were also studied. They were found to affect the function of different genes involved in gluconate metabolism.
摘要
分离并鉴定了一株在发酵平板上不发酵葡萄糖酸盐的大肠杆菌K-12突变体。该突变体命名为M2，在葡萄糖酸盐矿物培养基上生长存在较长的延迟期，并且在对数生长期其高亲和力转运、葡萄糖激酶和葡萄糖酸盐-6-磷酸脱水酶的活性水平有所降低。所涉及的突变位于malA附近。还研究了malA区域受影响的缺失突变体。发现它们影响参与葡萄糖酸盐代谢的不同基因的功能。
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