Pavlin J, Cheney F W
J Appl Physiol Respir Environ Exerc Physiol. 1979 Jan;46(1):31-5. doi: 10.1152/jappl.1979.46.1.31.
The effects of the mode of reinflation and of the duration of prior collapse on the development of unilateral pulmonary edema following reexpansion of collapsed lung were studied in a rabbit model simulating the human syndrome of "reexpansion pulmonary edema." The right lungs of rabbits were maintained in an atelectatic state for 0.5 h to 8 days, by injection of air into the pleural space. Reexpansion was achieved in 2 h by application of positive pressure to the airway while a chest tube was connected to underwater seal, or by application of negative pressure (-20 to -100 Torr) to a screened window in the partietal pleura. The lung surface pressures we actually applied by the two methods are not known. Animals were then killed and pulmonary edema was determined by wet-to-dry weight ratios. The incidence of unilateral pulmonary edema increased as the duration of prior collapse was increased (85% after 7--8 days; 17% after 3 days; and 0% after 0,5 h) when reinflated with -100 Torr applied to the pleural window. Although the incidence was less, it also occurred following the use of pleural window pressure less negative than -100 Torr, and after reinflation by positive airway pressure.
在一个模拟人类“复张性肺水肿”综合征的兔模型中，研究了再膨胀模式和先前萎陷持续时间对萎陷肺复张后单侧肺水肿发生发展的影响。通过向兔右侧胸腔内注入空气，使其右肺处于肺不张状态0.5小时至8天。通过在连接胸腔闭式引流时对气道施加正压2小时实现再膨胀，或者通过对壁层胸膜上的筛孔窗口施加负压（-20至-100托）来实现再膨胀。我们实际上通过这两种方法施加的肺表面压力尚不清楚。然后处死动物，通过湿重与干重之比来确定肺水肿情况。当对胸膜窗口施加-100托进行再膨胀时，单侧肺水肿的发生率随着先前萎陷持续时间的增加而增加（7 - 8天后为85%；3天后为17%；0.5小时后为0%）。尽管发生率较低，但在使用比-100托负压小的胸膜窗口压力后以及通过气道正压再膨胀后也会发生。
