Kan W O, Ledsome J R, Bolter C P
J Appl Physiol Respir Environ Exerc Physiol. 1979 Apr;46(4):625-31. doi: 10.1152/jappl.1979.46.4.625.
In chloralose-anesthetized dogs a constant-flow, right atrium-to-left pulmonary artery, right-heart bypass was created. The right lung root was completely occluded and an isolated pouch of the main pulmonary arteries was perfused with venous blood at controlled nonpulsatile pressures between 10 and 90 Torr. An increase in pulmonary arterial pouch pressure caused an increase in systemic arterial pressure and in respiratory drive. In animals with afferent nerves intact, the increase in respiratory drive was indicated by an increase in the amplitude of the integrated phrenic electroneurogram. In animals with the left vagus nerve cut immediately above the left lung root, the increase in respiratory drive was evident by a shortening of the time of expiration. All responses were abolished by bilateral section of the cervical vagosympathetic trunks. It is concluded that in the preparation described pulmonary arterial distension causes a reflex increase in systemic vascular resistance and in respiratory drive, the afferent path of the reflex being in the vagus nerves.
在水合氯醛麻醉的犬中，建立了一种恒流、从右心房到左肺动脉的右心旁路。右肺根被完全阻断，主肺动脉的一个孤立袋状结构在10至90托的可控非搏动压力下用静脉血灌注。肺动脉袋状结构压力的增加导致体动脉压和呼吸驱动增加。在传入神经完整的动物中，呼吸驱动的增加表现为膈神经综合电图幅度的增加。在左迷走神经在左肺根上方立即切断的动物中，呼吸驱动的增加通过呼气时间缩短而明显。双侧切断颈迷走交感干后，所有反应均消失。得出的结论是，在所描述的制备中，肺动脉扩张导致体循环血管阻力和呼吸驱动反射性增加，该反射的传入路径在迷走神经中。
