在对噬菌体λ呈溶原性的温度敏感型DNA突变体中，通过高温诱导原噬菌体。
Prophage induction by high temperature in thermosensitive dna mutants lysogenic for bacteriophage lambda.
作者信息
Schuster H, Beyersmann D, Mikolajczyk M, Schlicht M
出版信息
J Virol. 1973 Jun;11(6):879-85. doi: 10.1128/JVI.11.6.879-885.1973.
Abstract
High-temperature treatment of thermosensitive dna mutants lysogenic for phage lambda leads to prophage induction and release of phage (at the permissive temperature) in elongation-defective mutants of the genotypes dnaB, dnaE, and dnaG. In initiation-defective mutants no prophage induction occurs at 42 C in mutants of the genotype dnaA, whereas with a dnaC mutant as well as with strain HfrH 252 (map position not yet known) phages are released at 42 C. DNA degradation at the replication fork at 42 C is observed in all dnaB(lambda) mutants tested, but not in mutants of the genotypes dnaE(lambda) and dnaG(lambda). Therefore, degradation of replication fork DNA is not a prerequisite for prophage induction.
摘要
对携带噬菌体λ的溶原性热敏DNA突变体进行高温处理，在基因型为dnaB、dnaE和dnaG的延伸缺陷型突变体中会导致原噬菌体诱导和噬菌体释放（在允许温度下）。在起始缺陷型突变体中，基因型为dnaA的突变体在42℃时不会发生原噬菌体诱导，而对于dnaC突变体以及HfrH 252菌株（图谱位置未知），在42℃时会释放噬菌体。在所有测试的dnaB(λ)突变体中都观察到了42℃时复制叉处的DNA降解，但在基因型为dnaE(λ)和dnaG(λ)的突变体中未观察到。因此，复制叉DNA的降解不是原噬菌体诱导的先决条件。
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