Jones R W, Gregson N M, Elstein M
Br Med J. 1973 Jun 2;2(5865):520-3. doi: 10.1136/bmj.2.5865.520.
Intrauterine devices containing copper were introduced into cultures of adult and fetal cells. The Dalkon shield had no apparent effect on cell growth. The Gravigard device caused inhibition of growth and an increase in copper concentration in the supranatant medium. When the latter device was transferred through a series of subcultures the rate of release of copper decreased and growth was no longer inhibited.
含铜宫内节育器被引入成年细胞和胎儿细胞培养物中。达康盾对细胞生长没有明显影响。重力节育器导致生长抑制和上清培养基中铜浓度增加。当后一种节育器经过一系列传代培养时，铜的释放速率降低，生长不再受到抑制。
