含铜宫内节育器中铜的释放
Release of copper from copper-bearing intrauterine contraceptive devices.
作者信息
Chantler E, Critoph F, Elstein M
出版信息
Br Med J. 1977 Jul 30;2(6082):288-91. doi: 10.1136/bmj.2.6082.288.
Abstract
We measured the rate of release from copper-bearing intrauterine contraceptive devices (IUDs) with varying copper surface areas. Over 135 days of observation the release rate decreased exponentially. This decrease in the release rate was associated with the deposition of a protein layer on the surface of the metal. The bioavailability of copper on IUDs was not related to the volume of copper remaining on the device. Consequently any increase in the copper surface area of an IUD is unlikely to affect the duration of its copper-dependent contraceptive action.
摘要
我们测量了具有不同铜表面积的含铜宫内节育器（IUD）的释放速率。在135天的观察期内，释放速率呈指数下降。释放速率的这种下降与金属表面蛋白质层的沉积有关。IUD上铜的生物利用度与装置上剩余铜的量无关。因此，IUD铜表面积的任何增加都不太可能影响其依赖铜的避孕作用的持续时间。
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