van Noort R, Bayston R
J Biomed Mater Res. 1979 Jul;13(4):623-30. doi: 10.1002/jbm.820130408.
In an effort to find a solution to the serious problem of bacterial colonization of cerebrospinal-fluid shunting devices, room-temperature and heat-vulcanizing silicone rubbers were impregnated with gentamicin sulphate. The effects on the mechanical properties of the two rubbers were studied. Results show that the tensile strength and extensibility of the room-temperature-vulcanizing silicone rubber reduced with increasing concentration of the drug. For the heat-vulcanizing silicone rubber, the tensile strength was also found to decrease with increasing drug content. The extensibility after an initial reduction at low concentrations was found to increase at drug concentrations in excess of 10 mg/g. Nevertheless, the changes in mechanical properties measured are considered not to be so great as to preclude the application of drug-impregnated silicone rubbers to cerebrospinal-fluid shunting devices.
为了找到解决脑脊液分流装置细菌定植这一严重问题的方法，将硫酸庆大霉素浸渍到室温硫化硅橡胶和热硫化硅橡胶中。研究了这两种橡胶的力学性能受到的影响。结果表明，室温硫化硅橡胶的拉伸强度和伸长率随药物浓度的增加而降低。对于热硫化硅橡胶，也发现其拉伸强度随药物含量的增加而降低。在低浓度时伸长率最初降低，而在药物浓度超过10mg/g时伸长率增加。然而，所测得的力学性能变化被认为不至于妨碍将药物浸渍硅橡胶应用于脑脊液分流装置。
