一种能借助依赖DNA的RNA聚合酶无限增殖的RNA：从随机共聚物中筛选得到。
An RNA that multiplies indefinitely with DNA-dependent RNA polymerase: selection from a random copolymer.
作者信息
Biebricher C K, Orgel L E
出版信息
Proc Natl Acad Sci U S A. 1973 Mar;70(3):934-8. doi: 10.1073/pnas.70.3.934.
Abstract
We have selected from a mixture of random polynucleotides an RNA that is able to replicate in the presence of the DNA-dependent RNA polymerase of Escherichia coli, provided the medium contains Mn(2+) and ITP, in addition to ATP, CTP, and UTP. The RNA consists of a chain of about 125 (+/-25) nucleotides and appears to have a defined, nonrepetitive sequence.
摘要
我们从随机多核苷酸混合物中筛选出了一种RNA，只要培养基中除了含有ATP、CTP和UTP外，还含有Mn(2+)和ITP，这种RNA就能在大肠杆菌的DNA依赖性RNA聚合酶存在的情况下进行复制。该RNA由一条约125（±25）个核苷酸的链组成，并且似乎具有特定的、非重复的序列。
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