垂体与胰岛功能。I. 垂体切除对大鼠离体胰岛胰岛素分泌及胰岛素原和胰岛素生物合成的影响。 - Suppr

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Hypophysis and function of pancreatic islets. I. The influence of hypophysectomy on insulin secretion and biosynthesis of proinsulin and insulin in isolated pancreatic islets of rats.

作者信息

Schatz H, Rahman Y A, Hinz M, Fehm H L, Nierle C, Pfeiffer E F

出版信息

Diabetologia. 1973 Apr;9(2):135-9. doi: 10.1007/BF01230693.

DOI:10.1007/BF01230693

PMID:4577293

Abstract

摘要

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Hypophysis and function of pancreatic islets. I. The influence of hypophysectomy on insulin secretion and biosynthesis of proinsulin and insulin in isolated pancreatic islets of rats.垂体与胰岛功能。I. 垂体切除对大鼠离体胰岛胰岛素分泌及胰岛素原和胰岛素生物合成的影响。

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Studies on the conversion of proinsulin to insulin in the isolated islets of Langerhans in the rat.大鼠胰岛中胰岛素原向胰岛素转化的研究。

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Studies on the secretion of newly synthesized proinsulin and insulin from isolated rat islets of Langerhans.关于从分离的大鼠胰岛中分泌新合成的胰岛素原和胰岛素的研究。

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Persisting enhanced proinsulin-insulin and protein biosynthesis (3H-leucine incorporation) by pancreatic islets of the rat after glucose exposure.葡萄糖暴露后大鼠胰岛中持续增强的胰岛素原-胰岛素和蛋白质生物合成（3H-亮氨酸掺入）。

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Secretion of insulin in a perifusion system and conversion of proinsulin to insulin by pancreatic islets from hyperglycemic rats.在灌注系统中胰岛素的分泌以及高血糖大鼠胰岛将胰岛素原转化为胰岛素的过程。

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引用本文的文献

Diabetologia. 1973 Apr;9(2):140-4. doi: 10.1007/BF01230694.

Growth hormone regulation of DNA replication, but not insulin production, is partly mediated by somatomedin-C/insulin-like growth factor I in isolated pancreatic islets from adult rats.生长激素对DNA复制的调节作用（而非胰岛素分泌），部分是由成年大鼠分离胰岛中的生长调节素-C/胰岛素样生长因子I介导的。

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Role of the pituitary in cyproheptadine-induced pancreatic beta-cell toxicity.

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Maintenance of obesity following hypophysectomy in the obese-hyperglycemic mouse (ob/ob).肥胖-高血糖小鼠（ob/ob）垂体切除术后肥胖状态的维持

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本文引用的文献

Anterior Pituitary and Carbohydrate Metabolism.垂体前叶与碳水化合物代谢

Br Med J. 1939 Aug 19;2(4102):393-6. doi: 10.1136/bmj.2.4102.393.

The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma.人胰岛细胞腺瘤中胰岛素及胰岛素可能前体的生物合成。

Proc Natl Acad Sci U S A. 1967 Feb;57(2):473-80. doi: 10.1073/pnas.57.2.473.

Insulinlike activity of serum from normal and hypophysectomized monkeys.正常和垂体切除的猴子血清中的胰岛素样活性。

Endocrinology. 1963 Apr;72:658-61. doi: 10.1210/endo-72-4-658.

The influence of pituitary growth hormone on plasma insulin activity.垂体生长激素对血浆胰岛素活性的影响。

J Endocrinol. 1956 Apr;13(3):335-48. doi: 10.1677/joe.0.0130335.

Plasma-insulin activity in hypopituitarism assayed by the rat-diaphragm method.

Lancet. 1954 Apr 17;266(6816):809-10. doi: 10.1016/s0140-6736(54)91478-6.

Effect of growth hormone on the isolated pancreatic islets of rat in vitro.生长激素对体外培养的大鼠胰岛的作用。

Nature. 1967 Feb 11;213(5076):630-1. doi: 10.1038/213630a0.

Method for the isolation of intact islets of Langerhans from the rat pancreas.从大鼠胰腺中分离完整胰岛的方法。

Diabetes. 1967 Jan;16(1):35-9. doi: 10.2337/diab.16.1.35.

Effects of growth hormone and of hypophysectomy on the release of insulin from rat pancreas in vitro.

Acta Endocrinol (Copenh). 1965 Oct;50(2):202-12. doi: 10.1530/acta.0.0500202.

Acute effects of human chorionic somatomammotropin on insulin and glucagon release in the isolated perfused pancreas.人绒毛膜生长催乳素对离体灌注胰腺中胰岛素和胰高血糖素释放的急性影响。

Diabetes. 1972 Nov;21(11):1072-6. doi: 10.2337/diab.21.11.1072.

Decreased glucose tolerance in the rat following hypophysectomy.垂体切除术后大鼠葡萄糖耐量降低。

Endocrinology. 1971 May;88(5):1141-9. doi: 10.1210/endo-88-5-1141.

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