甲苯磺丁脲和格列本脲对分离的胰岛中（3H）亮氨酸掺入及胰岛素原向胰岛素转化的影响。 - Suppr

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超能文献

The effect of tolbutamide and glibenclamide on the incorporation of ( 3 H)leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets.

作者信息

Schatz H, Maier V, Hinz M, Nierle C, Pfeiffer E F

出版信息

FEBS Lett. 1972 Oct 1;26(1):237-40. doi: 10.1016/0014-5793(72)80581-7.

DOI:10.1016/0014-5793(72)80581-7

PMID:4629118

Abstract

摘要

相似文献

The effect of tolbutamide and glibenclamide on the incorporation of ( 3 H)leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets.甲苯磺丁脲和格列本脲对分离的胰岛中（3H）亮氨酸掺入及胰岛素原向胰岛素转化的影响。

FEBS Lett. 1972 Oct 1;26(1):237-40. doi: 10.1016/0014-5793(72)80581-7.

Long-term actions of sulfonylureas on (pro-) insulin biosynthesis and secretion: I. Lack of evidence for a compensatory increase in (pro-) insulin biosynthesis after exposure of isolated pancreatic rat islets to tolbutamide and glibenclamide in vitro.

Horm Metab Res. 1977 Nov;9(6):457-65. doi: 10.1055/s-0028-1093500.

Long-term actions of sulfonylureas on (Pro-) insulin biosynthesis and secretion. III. Functional state of isolated pancreatic rat islets after culture in the presence of tolbutamide and glibenclamide.磺酰脲类药物对（前）胰岛素生物合成及分泌的长期作用。III. 在甲苯磺丁脲和格列本脲存在的情况下培养后分离的大鼠胰岛的功能状态。

Horm Metab Res. 1981 Jul;13(7):411-2. doi: 10.1055/s-2007-1019284.

Long-term actions of sulfonylureas on (pro-)insulin biosynthesis and secretion. II. Studies after administration of tolbutamide and glibenclamide to rats in vivo.

Horm Metab Res. 1978 Jan;10(1):23-9. doi: 10.1055/s-0028-1093474.

[Long term in vivo and in vitro effect of sulfonylurea compounds on the islands of Langerhans of rat pancreas. Existence of a feedback mechanism between storage and synthesis apparatus of beta cells].[磺酰脲类化合物对大鼠胰腺朗格汉斯岛的长期体内外作用。β细胞储存与合成装置之间反馈机制的存在]

Verh Dtsch Ges Inn Med. 1977;83:1378-84.

Gastrointestinal hormones and function of pancreatic islets: studies on insulin secretion, 3H-leucine incorporation and intracellular free leucine pool in isolated pancreatic mouse islets.胃肠激素与胰岛功能：对分离的小鼠胰岛胰岛素分泌、3H-亮氨酸掺入及细胞内游离亮氨酸池的研究

Endocrinology. 1974 Jan;94(1):248-53. doi: 10.1210/endo-94-1-248.

Studies on the conversion of proinsulin to insulin in the isolated islets of Langerhans in the rat.大鼠胰岛中胰岛素原向胰岛素转化的研究。

Can J Physiol Pharmacol. 1973 Mar;51(3):175-82. doi: 10.1139/y73-025.

(Pro-) insulin biosynthesis and release of newly synthesized (pro-) insulin from isolated islets of rat pancreas in the presence of amino acids and sulphonylureas.（前）胰岛素的生物合成以及在氨基酸和磺脲类药物存在的情况下，从大鼠胰腺分离胰岛中释放新合成的（前）胰岛素。

Eur J Clin Invest. 1975 Nov 21;5(6):477-85. doi: 10.1111/j.1365-2362.1975.tb00480.x.

An inhibitory effect of tolbutamide and glibenclamide (glyburide) on the pancreatic islets of normal animals.甲苯磺丁脲和格列本脲（优降糖）对正常动物胰岛的抑制作用。

Diabetologia. 1974 Feb;10(1):27-35. doi: 10.1007/BF00421411.

[The effect of oral antidiabetics on the biosynthesis of proinsulin in the rat].[口服抗糖尿病药物对大鼠胰岛素原生物合成的影响]

Arzneimittelforschung. 1972 Nov;22(11):1890-2.

引用本文的文献

Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways.格列本脲通过钙依赖性的mTOR、PKA和MEK信号通路激活大鼠胰腺β细胞中的翻译过程。

Diabetologia. 2008 Jul;51(7):1202-12. doi: 10.1007/s00125-008-1026-8. Epub 2008 May 21.

Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.艾塞那肽4主要通过在翻译水平增强葡萄糖刺激的胰岛素原生物合成来控制大鼠胰岛β细胞中的胰岛素产生。

Diabetologia. 2006 Dec;49(12):2920-9. doi: 10.1007/s00125-006-0433-y. Epub 2006 Oct 20.

Metabolic, cationic and secretory effects of hypoglycemic sulfonylureas in pancreatic islets.降糖磺脲类药物对胰岛的代谢、阳离子及分泌作用

Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312(3):277-83. doi: 10.1007/BF00499158.

Long-term effects of glibenclamide on the insulin production, oxidative metabolism and quantitative ultrastructure of mouse pancreatic islets maintained in tissue culture at different glucose concentrations.格列本脲对在不同葡萄糖浓度下于组织培养中维持的小鼠胰岛胰岛素分泌、氧化代谢及定量超微结构的长期影响。

Acta Diabetol Lat. 1981;18(1):65-83. doi: 10.1007/BF02056108.

Insulin secretion and (pro)insulin biosynthesis of cultured mice islets after glibenclamide loading in vitro.体外给予格列本脲后培养的小鼠胰岛的胰岛素分泌及（前）胰岛素生物合成

Experientia. 1980 Apr 15;36(4):467-8. doi: 10.1007/BF01975151.

Tolbutamide-induced changes of the DNA, protein and insulin content and the secretory activity of isolated rat pancreatic islets.

Diabetologia. 1975 Aug;11(4):301-5. doi: 10.1007/BF00422395.

Effect of tolbutamide on aminophylline-, 3,5-AMP-dibutyrate- or glucagon-induced insulin release from pancreatic islets after impairment of pyridine nucleotide metabolism caused by 6-aminonicotinamide (6-AN).6-氨基烟酰胺（6-AN）导致吡啶核苷酸代谢受损后，甲苯磺丁脲对氨茶碱、3,5-AMP-二丁酸酯或胰高血糖素诱导的胰岛胰岛素释放的影响。

Naunyn Schmiedebergs Arch Pharmacol. 1975;290(2-3):251-64. doi: 10.1007/BF00510554.

Biosynthesis of proinsulin and insulin in newborn rat pancreas. Interaction of glucose, cyclic AMP, somatostatin, and sulfonylureas on the (3H) leucine incorporation into immunoreactive insulin.新生大鼠胰腺中胰岛素原和胰岛素的生物合成。葡萄糖、环磷酸腺苷、生长抑素和磺脲类药物对（3H）亮氨酸掺入免疫反应性胰岛素的相互作用。

J Clin Invest. 1976 Jan;57(1):230-43. doi: 10.1172/JCI108264.

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