哺乳动物细胞DNA纤维中复制的时间组织
Temporal organization of replication in DNA fibers of mammalian cells.
作者信息
Jasny B R, Tamm I
出版信息
J Cell Biol. 1979 Jun;81(3):692-7. doi: 10.1083/jcb.81.3.692.
Abstract
The extent of coordinate control over the multiple initiation events in DNA replication has been investigated in three mammalian cell lines by DNA fiber autoradiography. Quantitative estimates have been obtained of the degree of synchrony among initiations occurring on stretches of DNA. Synchrony decreases markedly with increasing distance between initiation sites in MDBK (bovine) and L929 (mouse) cells, but only slightly in muntjac cells. Possible control mechanisms for the initiation process are discussed.
摘要
通过DNA纤维放射自显影技术，在三种哺乳动物细胞系中研究了对DNA复制中多个起始事件的协同控制程度。已获得了对DNA片段上起始事件之间同步程度的定量估计。在MDBK（牛）细胞和L929（小鼠）细胞中，同步性随着起始位点之间距离的增加而显著降低，但在 muntjac 细胞中仅略有降低。文中讨论了起始过程可能的控制机制。
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