Rosen O M, Chia G H, Fung C, Rubin C S
J Cell Physiol. 1979 Apr;99(1):37-42. doi: 10.1002/jcp.1040990106.
Tunicamycin, an antibiotic that inhibits protein glycosylation, elicited a rapid depletion of insulin binding activity at the surface of 3T3-L1 adipocytes. Disappearance of insulin receptors occurred more rapidly in the presence of tunicamycin than when protein synthesis was inhibited by cycloheximide and was accompanied by a diminution in sensitivity of the adipocytes to the acute effects of insulin and anti-insulin receptor antibody on hexose uptake and metabolism.
衣霉素是一种抑制蛋白质糖基化的抗生素，它能使3T3-L1脂肪细胞表面的胰岛素结合活性迅速降低。与用环己酰亚胺抑制蛋白质合成时相比，在衣霉素存在的情况下胰岛素受体的消失更快，同时脂肪细胞对胰岛素和抗胰岛素受体抗体对己糖摄取和代谢的急性作用的敏感性也降低。
