Hamoen A M
Br Med J. 1973 Aug 4;3(5874):272-3. doi: 10.1136/bmj.3.5874.272.
In a patient probably suffering from Jakob-Creutzfeldt disease of the Jones-Nevin type and in another with a cerebral infarction treatment with amantadine (Symmetrel) 100 mg twice a day caused repetitive triphasic waves to disappear from the E.E.G. in each case. In view of these findings and the fact that some other conditions in which repetitive triphasic E.E.G. waves are a clinical feature greatly improve on treatment with levodopa, the suggestion is made that these waves result from a disorder of the dopaminergic system.
在一名可能患有琼斯 - 内文型雅各布 - 克雅氏病的患者以及另一名患有脑梗死的患者中，每天两次服用100毫克金刚烷胺（Symmetrel）进行治疗，使得这两名患者脑电图中的重复性三相波均消失。鉴于这些发现以及其他一些以重复性三相脑电图波为临床特征的病症在左旋多巴治疗后有显著改善这一事实，有人提出这些波是由多巴胺能系统紊乱导致的。
