Sanders W L, Dunn T L
J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):581-4. doi: 10.1136/jnnp.36.4.581.
The treatment of two cases of Creutzfeldt-Jakob disease with amantidine is described. The first case made a remarkable initial improvement which was sustained for two months, but then deteriorated and died. Histological examination of the brain showed changes consistent with early Creutzfeldt-Jakob disease. The second case which was clinically one of Creutzfeldt-Jakob disease has now been followed for 30 months since the start of treatment and appears to be cured. It is considered that amantidine has a definite effect in this disease and it is suggested that its mode of action, though unknown, is more likely to be metabolic than antiviral.
描述了用金刚烷胺治疗两例克雅氏病的情况。第一例最初有显著改善，持续了两个月，但随后病情恶化并死亡。脑组织学检查显示的变化与早期克雅氏病一致。第二例临床诊断为克雅氏病，自开始治疗以来已随访30个月，似乎已治愈。认为金刚烷胺对该病有确切疗效，其作用方式虽尚不清楚，但更可能是代谢性的而非抗病毒性的。
