Mulé J J, Jones F R, Hellström I, Hellström K E
J Immunol. 1979 Aug;123(2):600-6.
Newly formed long-lived small lymphocytes (LLSL) generated during the immunization of mice to tumor specific transplantation antigens (TSTA) of syngeneic MCA-induced sarcomas were labeled. We then studied the localization of these labeled cells into tumor implants. "Crisis-cross" experiments were performed in which MCA sarcomas with individually distinct TSTA were studied in parallel. A selective localization of LLSL into tumors to which the lymphocytes were immune was found when small tumor pieces were implanted into immune mice whose LLSL had been labeled. Selective localization was also detected upon adoptive transfer of immune LLSL to tumor-bearing mice, but only when these mice had, before transfer, received a sublethal dose of whole body irradiation.
在将小鼠免疫于同基因甲基胆蒽诱导肉瘤的肿瘤特异性移植抗原（TSTA）过程中产生的新形成的长寿小淋巴细胞（LLSL）被标记。然后我们研究了这些标记细胞在肿瘤植入物中的定位。进行了“交叉”实验，其中并行研究了具有各自不同TSTA的甲基胆蒽肉瘤。当将小肿瘤块植入其LLSL已被标记的免疫小鼠体内时，发现LLSL选择性地定位于淋巴细胞免疫的肿瘤中。在将免疫的LLSL过继转移给荷瘤小鼠时也检测到了选择性定位，但前提是这些小鼠在转移前接受了亚致死剂量的全身照射。
