Inaba M, Anthony J, McKinstry C
J Invest Dermatol. 1979 May;72(5):224-31. doi: 10.1111/1523-1747.ep12530773.
It was observed that after subcutaneous tissue shaving for the radical therapy of hircismus and hyperhidrosis axillary hair often regrew. Histologic study of this phenomenon showed that hair bulb and most of the follicle up to a level near the sebaceous duct opening had been removed. Hair regrows from remnant outer root sheath, but only when sebaceous glands are preserved, that is when the upper portion of the follicular isthmus is intact. One or several solid epithelial pegs grow downward from the cut end of the trichilemma, and inner root sheath and new young hair are formed in its center. In hair peg stage, the lower tip of the hair follicle descends while new hair is growing in its center through the mitotic activity is growing in its center through the mitotic activity of hair germ cells and is prevented from pushing toward the skin surface by interlocking fusion between hair cuticula and sheath cuticula. Eventually, the epithelial cells wrap around a mass of mesenchymal cells and form a new bulb from which the terminal hair grows upward. The new matrix acquires a new complement of functioning melanocytes.
据观察，在为治疗腋臭和多汗症而进行皮下组织刮除术后，腋毛常可再生。对这一现象的组织学研究表明，毛球和大部分毛囊直至皮脂腺导管开口附近的水平都已被去除。毛发从残留的外根鞘再生，但仅在皮脂腺得以保留时，即毛囊峡部的上部完整时才会如此。一个或几个实性上皮钉从毛乳头的切割端向下生长，其中心形成内根鞘和新的幼毛。在毛钉阶段，毛囊的下端下降，而新毛在其中心通过毛胚细胞的有丝分裂活动生长，并因毛小皮与鞘小皮之间的连锁融合而无法向皮肤表面推进。最终，上皮细胞围绕一团间充质细胞包裹并形成一个新的毛球，终毛从该毛球向上生长。新的毛基质获得了一批有功能的黑素细胞。
